This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Small molecule interactions
Molecules that interact with a gene product could be of significant value, especially when the gene product is known to be associated with diseases. These molecules could be identified via searches in PubChem. 4 bioassays were shown to be related to Notch1, 2 of which are particularly interesting for the purpose of identifying molecules that interact with Notch1. 61 compounds were identified in the first bioassay, whereas 3 were identified in the second. Shown below are 3 of the compounds from the first bioassay and a compound from the second bioassay.
The compounds below are from bioassay AID: 434982. These compounds are agonists of NOTCH.
Molecule 1: AC1Q2GQW
Molecule 1: AC1Q2GQW
Molecule 2: AC1O4CHH
Molecule 3: ZINC01041509
_The molecule below is from bioassay AID: 263959. The compounds detected in this bioassay did not directly target Notch1. Instead, it targets
gamma-secretase that is required for the maturation and correct
processing of Notch1.
Molecule 1:
Analysis:
The second bioassay was performed on fibroblast cell line. Although this is not directly related to T-ALL, the molecules identified in the bioassay may also be applicable to Notch1-induced T-ALL, as the disease is associated with overexpression/hyperactivity of Notch1 signaling.