This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Gene ontology
Gene ontology defines the characteristics of gene products [AmiGO]. The following results for NOTCH1 gene ontology were obtained from AmiGO. Click on each listed entry for more information.
Biological processes:
Cell fate specification
Immune response
Negative regulation of anoikis
Notch receptor processing
Positive regulation of transcription of Notch receptor target
Positive regulation of cell proliferation
Positive regulation of epithelial to mesenchymal transition
Cellular component:
Cytoplasm
Cytosol
Endoplasmic reticulum lumen
Nucleus
Plasma membrane
Nucleoplasm
Molecular function:
Chromatin DNA binding
Core promoter binding
Protein binding
Biological processes:
Cell fate specification
Immune response
Negative regulation of anoikis
Notch receptor processing
Positive regulation of transcription of Notch receptor target
Positive regulation of cell proliferation
Positive regulation of epithelial to mesenchymal transition
Cellular component:
Cytoplasm
Cytosol
Endoplasmic reticulum lumen
Nucleus
Plasma membrane
Nucleoplasm
Molecular function:
Chromatin DNA binding
Core promoter binding
Protein binding
Analysis
The ontology of NOTCH1 (especially its molecular function) shows that the gene product plays important role in signaling events and transcriptional regulation, possibly by formation of protein complexes. The targets for transcriptional regulation may be involved in cell cycle progression of various cell types, as suggested by the biological processes in which NOTCH1 plays a role. AmiGO also identified the cellular components in which NOTCH1 products could be found. The results are consistent with the known role of NOTCH1 product as transmembrane receptor that, when bound by its ligand, is further processed and cleaved into smaller components which then translocate to the nucleus.
The ontology of NOTCH1 (especially its molecular function) shows that the gene product plays important role in signaling events and transcriptional regulation, possibly by formation of protein complexes. The targets for transcriptional regulation may be involved in cell cycle progression of various cell types, as suggested by the biological processes in which NOTCH1 plays a role. AmiGO also identified the cellular components in which NOTCH1 products could be found. The results are consistent with the known role of NOTCH1 product as transmembrane receptor that, when bound by its ligand, is further processed and cleaved into smaller components which then translocate to the nucleus.